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Effect of glucosamine on interleukin-1-conditioned articular cartilage

https://pubmed.ncbi.nlm.nih.gov/12405690/ (PDF)

A review of articular cartilage pathology and the use of glucosamine sulfate

https://pubmed.ncbi.nlm.nih.gov/16558667/ (PDF)

Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind study

https://pubmed.ncbi.nlm.nih.gov/12374520/ (PDF)

Randomised double-blind, positive-controlled trial to assess the efficacy of glucosamine/chondroitin sulfate for the treatment of dogs with osteoarthritis

"Thirty-five dogs were included in a randomised, double-blind, positive controlled, multi-centre trial to assess the efficacy of an orally-administered glucosamine hydrochloride and chondroitin sulfate (Glu/CS) combination for the treatment of confirmed osteoarthritis of hips or elbows. [...] Response to treatment was based on subjective evaluation by participating veterinarians who recorded their findings at each visit. Dogs treated with Glu/CS showed statistically significant improvements in scores for pain, weight-bearing and severity of the condition by day 70. [...] The results show that Glu/CS has a positive clinical effect in dogs with osteoarthritis."

https://pubmed.ncbi.nlm.nih.gov/16647870/

Nutraceuticals as therapeutic agents in osteoarthritis. The role of glucosamine, chondroitin sulfate, and collagen hydrolysate

https://pubmed.ncbi.nlm.nih.gov/10356424/ (PDF auf Anfrage)

Glucosamine and chondroitin for osteoarthritis

https://pubmed.ncbi.nlm.nih.gov/19094424/ (PDF)

EULAR Recommendations 2003: an evidence based approach to the management of knee osteoarthritis: Report of a Task Force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT)

https://ard.bmj.com/content/62/12/1145.long (PDF)

Comparative therapeutic efficacy and safety of type-II collagen (UC-II), glucosamine and chondroitin in arthritic dogs: pain evaluation by ground force plate

"Dogs receiving UC-II (Group-II) showed significant reduction in pain by day 60, but the maximum reduction in pain was observed on day 150 (overall pain, 81%; pain after limb manipulation, 87%; and pain after physical exertion, 90%). Group-III dogs receiving GLU + CHO exhibited significant reduction in pain by day 90 with maximal effects on day 150 (overall pain, 51%; pain after limb manipulation, 48%; and pain after physical exertion, 43%) [...] None of the dogs receiving dietary supplements showed any signs of adverse effects."

https://pubmed.ncbi.nlm.nih.gov/21623931/

Clinical efficacy and tolerance of an extract of green-lipped mussel (Perna canaliculus) in dogs presumptively diagnosed with degenerative joint disease

https://pubmed.ncbi.nlm.nih.gov/16751841/ (PDF)

Influence of green lipped mussels (Perna canaliculus) in alleviating signs of arthritis in dogs

"This study evaluated the efficacy of green lipped mussel (GLM), added to a complete dry diet, for alleviating clinical signs of arthritis in dogs. A double-blind longitudinal study design was used with 31 mixed-breed dogs exhibiting varying degrees of arthritis. Each dog was evaluated by a veterinarian and joints were individually scored for degree of pain, swelling, crepitus, and reduction in range of movement. Summation of all scores for an individual dog comprised its total arthritis score. At baseline, dogs were randomly allocated to control and test groups. Both groups were fed the same base dry diet, to which 0.3% GLM powder was added for dogs in the test group. The change in total arthritis score by the end of 6 weeks showed there was significant improvement (P <.05) in the test group versus the control group. Significant improvements were also observed in joint pain and swelling scores in the test group. Changes in joint crepitus and range of joint movement were not significantly different between the test and control groups. These findings provide strong evidence that GLM incorporated into a complete dry diet can help alleviate arthritis symptoms in dogs."

https://pubmed.ncbi.nlm.nih.gov/15136981/ (PDF auf Anfrage)

Effect of a diet enriched with green-lipped mussel on pain behavior and functioning in dogs with clinical osteoarthritis

https://pubmed.ncbi.nlm.nih.gov/23814358/ (PDF)

Evaluating Complementary Therapies for Canine Osteoarthritis Part I: Green-lipped Mussel (Perna canaliculus)

https://pubmed.ncbi.nlm.nih.gov/18955269/ (PDF)

Studie untersucht den Effekt auf die Knochenregeneration bei Hunden nach Einnahme von Vitamin D3

Association of vitamin D3 with alveolar bone regeneration in dogs

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459836/ (PDF)

Studien untersuchten die Wirksamkeit von Vitamin D3 bei der Knochenbildung -und heilung.

The Effect of Vitamin D and Its Metabolites on Fracture Repair in Chicks

https://pubmed.ncbi.nlm.nih.gov/6309464/

24R,25-dihydroxyvitamin D3: an essential vitamin D3 metabolite for both normal bone integrity and healing of tibial fracture in chicks

https://pubmed.ncbi.nlm.nih.gov/9275076/ (PDF)

Short-term treatment of rats with high dose 1,25-dihydroxyvitamin D3 stimulates bone formation and increases the number of osteoblast precursor cells in bone marrow

https://pubmed.ncbi.nlm.nih.gov/9348188/ (PDF)

Anti-inflammatory response of dietary vitamin E and its effects on pain and joint structures during early stages of surgically induced osteoarthritis in dogs

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3700444/ (PDF)

Penberthy WT, Sadri M, Zempleni J (2020). "Biotin". In BP Marriott, DF Birt, VA Stallings, AA Yates (eds.). Present Knowledge in Nutrition, Eleventh Edition. London, United Kingdom: Academic Press (Elsevier). pp. 289–304.

https://www.sciencedirect.com/topics/earth-and-planetary-sciences/biotin

Combination of chromium and biotin improves coronary risk factors in hypercholesterolemic type 2 diabetes mellitus: a placebo-controlled, double-blind randomized clinical trial

https://pubmed.ncbi.nlm.nih.gov/17684468/